‘Personalized and Safe Therapy’ was the title of the 41st European Society of Clinical Pharmacy (ESCP) Symposium on Clinical Pharmacy, held on 28–31 October 2012 in Barcelona, Spain. The symposium was attended by ≈700 participants, featured numerous lectures and workshops, and included the presentation of >400 posters and oral communications. This report highlights information from selected plenary lectures that discussed methods of performing clinical pharmacy with the goal of ensuring that the individual patient receives the best possible therapy and health outcomes.