A postdoc position for two years and a half (starting in 2022 and finishing
in August 31st 2024) with a possible extension of 6 additional months is
open at the Laboratory of Molecular Neuropharmacology and
Bioinformatics (Institut de Neurociències, Universitat Autònoma de
Barcelona), headed by Dr. Jesús Giraldo, to work on Molecular Dynamics
simulations of G protein-coupled receptors (GPCRs).
The position is linked to the Spanish Ministerio de Ciencia e Innovación
grant “Assessing the functional complexity of GPCRs through
computational methods: chronic pain from a molecular pharmacology
perspective” Ref. PID2020-119136RB-I00.
The project involves molecular dynamics simulations of opioid receptors
including intrinsic efficacy (partial/inverse agonism), receptor
heteromerization and biased signaling pharmacological topics.
Selected References:
1.-Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor:
Morphine and Fentanyl Elicit Different Activation Patterns. Ricarte
A, Dalton JAR, Giraldo J. J Chem Inf Model. 2021;61(3):1251-1274
2.-Insights into adenosine A2A receptor activation through cooperative
modulation of agonist and allosteric lipid interactions. Bruzzese A,
Dalton JAR, Giraldo J. PLoS Comput Biol. 2020;16(4):e1007818
3.-Revealing the Mechanism of Agonist-Mediated Cannabinoid
Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric
Modulation. Díaz Ó, Dalton JAR, Giraldo J. J Med Chem.
2019;62(11):5638-5654
Code Position: 2021DILEUA111 – Investigador ordinari
INFORMATION: https://tauler.seu.cat/pagDetall.do?idEdicte=339081&idens=11

Applications should be made through: https://forms.office.com/r/bGJCMiYKfm
APPLICATION DEADLINE: 11/02/2022