Líneas de investigación
- Study the mechanisms involved in cerebral and peripheral vascular pathology after ischemia/reperfusion episodes and find potential cerebroprotective strategies
- Study cerebrovascular pathology in rare diseases
- Evaluate the mechanisms involved in Marfan syndrome aortic pathology and therapeutic strategies
- Assess the impact of TRPV2 signaling in the vasculature
Metodología in vitro
- Wire myography
- Pressure myography
- Large and small vessel angiogenesis
- Measurements of superoxide anion levels by HPLC in biological tissues
Metodología in vivo
- Transient intraluminal occlusion of the middle cerebral and carotid artery (in mice and rats)
- Ovariectomy (in mice and rats)
- Measurements of cerebral blood flow by Laser Doppler and Laser Speckle systems
Equipamiento
- SIMACE (Servicio de Microscopía Confocal y Electrónica)
- SeGeFun (Servicio de Genómica Funcional)
- Laboratorio de Cribado Farmacológico para cribar librerías químicas
- Sistemas bioinformáticos para cribado in sílico y modelización molecular.
Disponibilidad/Acceso a Animales Modificados Genéticamente
- Fbn1C1041G/+ mice (Marfan syndrome) / wild-type (C57BL/6)
Disponibilidad/Acceso a Bancos de Células, Tejidos, Órganos
- Aortas, arterias cerebrales, cerebro, corazon, ojos, penes de ratones Fbn1C1041G/+ y wild-type (C57BL/6); males and females; young (2-3 mo) and aged (12 mo)
